Bioactive Small Molecules
Cayman Chemical ANTIBODY EbastIn 1g
A histamine H1 receptor antagonist and prodrug form of carebastine; binds to histamine H1 receptors (IC50 = 45 nM); selective for histamine H1 receptors over α1-adrenergic and muscarinic M1 and M2 receptors (IC50s = 183, 1,100, and >10,000 nM, respectively), as well as dopamine D2 and 5-HT1A receptors at 1 and 10 µM, respectively; inhibits T cell proliferation and the production of IL-4 and IL-5 in isolated human T cells at 1, 5, and 10 µM; inhibits histamine-induced and allergen-induced bronchospasm in guinea pigs (ED50s = 115 and 334 UG/kg, respectively)
Cayman Chemical ANTIBODY BudesonIde 50mg
A glucocorticoid and an agonist of glucocorticoid receptors (EC50 = 45.7 pM in a transactivation assay); selective for glucocorticoid over mineralocorticoid receptors (EC50 = 7,620 pM); inhibits LPS-induced TNF-α release from human PBMCs (IC500 = 0.96 nM); reduces levels of IL-1β and eotaxin in the lungs and the number of eosinophils and neutrophils in BALF in a rat model of ovalbumin-induced airway inflammation at 3 mg/kg; intracolonic administration decreases colon wet weight and colonic MPO activity in a rat model of oxazolone-induced colitis
Cayman Chemical ANTIBODY X-Gal 5g
A chromogenic substrate for β-galactosidase; upon cleavage, a blue pigment is released that can be used as a marker of β-galactosidase activity; has been used for the detection of lacZ activity in reporter assays and in the determination of protein-protein interactions
Cayman Chemical ANTIBODY PR-619 50mg
A general inhibitor of DUBs, significantly reducing the activity of a panel of DUBs with EC50 values ranging from 5-20 µM; cell-permeable and reversible in its action
Cayman Chemical ANTIBODY LucIgenIn 500mg
A chemiluminescent probe; used to detect superoxide production by enzymatic and cellular sources; produces similar chemiluminescence in isolated aortic and cardiac tissues from wild-type and Nox1-Nox2-Nox4 triple knockout mice, suggesting that it is not selective for NADPH-based ROS production; reacts with hydrogen peroxide without generating free radical intermediates; a fluorescent chloride-sensitive indicator, with its fluorescence being quenched by chloride (ex/em = 455/505 nm, respectively)
Cayman Chemical GInsenosIde Rb1 5mg
A triterpene saponin with diverse biological activities; decreases apoptosis and increases in PKA, PKC, caspase-3, and caspase-9 levels in H9c2 rat cardiomyocytes at 100 µM; inhibits glucose-induced cytotoxicity and production of ROS in primary rat hippocampal neurons at 1 µM; inhibits LPS-induced activation of IRAK1, IΚΚβ, NF-κB, as well as the MAP kinases ERK, JNK, and p38, in mouse peritoneal lavage fluid at 100 µM; increases hippocampus nestin and GFAP levels in a rat model of Alzheimer’s disease induced by Aβ40 at 10 mg/kg for 30 days; decreases high-fat diet-induced increases in liver weight, hepatic triglyceride accumulation, serum fasting glucose levels, and serum LDL levels in a mouse model of obesity at 200 mg/kg per day
Cayman Chemical ANTIBODY SalubrInal 5mg
A selective phosphatase inhibitor which prevents dephosphorylation of eIF2α, protecting cells from ER stress-mediated apoptosis (EC50 = 15 μM); prevents replication of herpes virus (IC50 = 3 μM) and alters bone formation
Cayman Chemical ANTIBODY SN-38 50mg
An inhibitor of topoisomerase I and an active metabolite of irinotecan; induces topoisomerase I-dependent DNA cleavage in a cell-free assay at 0.1, 1, and 10 µM; induces DNA single-strand breaks in HT-29 cells at 200 nM; induces cytotoxicity in HT-29 cells (IC50 = 8.8 nM); reduces tumor volume without affecting body weight in an MX-1 breast cancer mouse xenograft model at 100 mg/kg per day
Cayman Chemical ANTIBODY CalpeptIn 5mg
A cell-penetrating peptide inhibitor of calpain (IC50 = 5 nM) which completely abolishes calpain activity in platelets; also a potent inhibitor of cathepsin K (IC50 = 0.11 nM)
Cayman Chemical 25I-NBOHhydrochlorIde 5mg
A derivative of 2C-I that acts as a potent agonist for the human serotonin 5-HT2A receptor (Ki = 0.061 nM); intended for research and forensic applications
Cayman Chemical ANTIBODY Fluo-3 AM 1mg
A cell-permeable AM ester of the fluorescent calcium indicator fluo-3
Cayman Chemical ANTIBODY BudesonIde 100mg
A glucocorticoid and an agonist of glucocorticoid receptors (EC50 = 45.7 pM in a transactivation assay); selective for glucocorticoid over mineralocorticoid receptors (EC50 = 7,620 pM); inhibits LPS-induced TNF-α release from human PBMCs (IC500 = 0.96 nM); reduces levels of IL-1β and eotaxin in the lungs and the number of eosinophils and neutrophils in BALF in a rat model of ovalbumin-induced airway inflammation at 3 mg/kg; intracolonic administration decreases colon wet weight and colonic MPO activity in a rat model of oxazolone-induced colitis
Cayman Chemical ANTIBODY Nocodazole 10mg
An antimitotic agent; increases tubulin GTP hydrolysis and induces depolymerization; halts the cell cycle in the mitotic phase and synchronizes WI38 cells in the G2/M phase at 4 UG/ml; decreases neuronal mitochondrial transport and density in a transgenic zebrafish model with neurons expressing fluorescent proteins in mitochondrial and cell membranes at 400 nM
Selleck Chemical LLC TVB-3166-5mg
TVB-3166 is an orally-available, reversible, potent and selective inhibitor of fatty acid synthase (FASN) with IC50 of 0.042 μM in an in vitro biochemical assay. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth.
AdipoGen Jasplakinolide (high purity) (50 µg)
Jasplakinolide (high purity) (50 µg), AdipoGen Life Sciences. Chemical. CAS: 102396-24-7. Formula: C36H45BrN4O6. MW: 709.7. Isolated from Jaspis splendens. Cell permeable, non-fluorescent F-actin probe. Potent inducer of actin polymerization and stabilization. Competes with phallotoxins for actin binding. Antifungal and antiparasitic compound. Antiproliferative and anticancer compound. Apoptosis enhancer/inducer. Tool used for autophagy/phagocytosis research.